How Does the Product Work?

This advanced system provides documented validity and reliability for veterinary applications. The system consists of two components.

• The first is a hand-held analyzer that drives the analysis cycle from its microprocessor.

• The second is a disposable test cartridge which contains miniaturized fluidic and biosensor functions.

ERROR MSGBlood is introduced by the user into the cartridge. When the cartridge is introduced into the analyzer, it performs a self-calibration and quality checks using fluids in the cartridge and then moves blood over the various electrode sensors. Individual assays are performed by electrochemical methods and are detected by the analyzer as current changes. Results are viewed on an LCD screen in less than 2 minutes.

Fill cartridge with 3 drops of fresh whole blood and seal	Insert cartridge into analyzer	ERROR MSGView results in less than 2 minutes

The system has cartridge applications relevant for immediate treatment decisions in blood chemistry, hematocrit, electrolytes, acid-base status, and coagulation.

• ERROR MSGFrom venipuncture to results, whole blood analysis in less than 2 minutes using less than 100l of blood
• Chemistry, electrolyte, and acid base results most relevant to immediate treatment decisions
• Hand-held, self-powered, highly portable device
• Automated analysis cycle; required user expertise limited to placing blood in cartridge
• Ability to store, print, and download patient data results
• Self-calibrating, no user maintenance
• Complete service and support

   

The i-STAT system's features of speed, simplicity, and analyte menus make it ideally suited for patient side diagnostic testing. It provides chemistry, electrolyte, and acid-base results that are most important for immediate treatment decisions. It is intended to supplement more comprehensive biochemical profiling that involves considerably longer turnaround time. More importantly, once a diagnosis has been made, the i-STAT system is ideal for monitoring results most relevant to real-time treatment decisions.

Applications and applicable cartridges are outlined below:

• Internal medicine:
  
  - Animal-side diagnosis and monitoring that supports immediate treatment decisions for the complicated medical patient
  
  - Whole blood analysis in less than 2 minutes on a hand-held analyzer

• Critical care/emergency clinic environments:
  
  - Rapid real-time diagnostics that support immediate treatment decisions

EC8+ Cartridge: Chemistry, electrolytes, acid base status

EG7+ Cartridge: Electrolytes, Ionized Ca, complete acid-base panel

CG4+ Cartridge: Introducing lactate with complete acid-base panel

View Cartridge Configuration Detail

Additional applications

• Real-time preanesthetic and wellness testing
  
  - Testing as the animal is staged for anesthesia; eliminates duplicate client visits and animal holdover

6+ cartridge: Chemistry, hematocrit, and electrolytes

• Glucose monitoring

G Cartridge: Accurate whole blood glucose in less than 2 minutes

• Coagulation screening test

- Introducing the Actvated Coagulation Time screening test; rapid screening for most coagulation abnormalities

^CeliteACT Cartridge: Screening test for intrinsic and common pathway coagulation factor deficiencies

• Creatinine

back to top   Performance Data

The i-STAT system has been extensively evaluated along side reference laboratory procedures in both human health and animal health. In animal health, the system has been independently tested in veterinary institutions using readily available reference comparison procedures. These data have been disseminated to the veterinary profession in the form of several referred publications. For more information, refer to the next section, "References".

back to top   Published References

i-STAT Publications:

¹ Grosenbaugh DA, Gadawski JE, Muir WW. Evaluation of a portable clinical analyzer in a veterinary hospital setting. JAVMA Vol 213, No. 5, September 1, 1998, p691- 694.

Abstracted Clinical Conclusions: "Most differences between values obtained with the portable clinical analyzer and standard clinical laboratory systems could be accounted for by differences in type of sample tested (blood vs serum). The portable clinical analyzer is suitable for point-of-care analysis in critical care situations and for routine blood biochemical analysis when extensive laboratory support is unavailable."

² Looney AL, Ludders J, Erb HN, et al. Use of a handheld device for analysis of blood electrolyte concentrations and blood gas partial pressures in dogs and horses. JAVMA Vol 213, No. 4, August 15, 1998, p526 530.

Abstracted Clinical Conclusions: "Results obtained with the hand-held analyzer were similar to those obtained from the standard chemistry analyzer, with the exception of sodium concentration for canine samples and Hct for equine sample."

³ Cohn LA, McCaw DL, Tate DJ et al. Assessment of five portable blood glucose meters, a point-of-care analyzer, aond color test strips for measuring blood glucose concentration in dogs. JAVMA Vol 216, No. 2, January 15, 2000, p198 202.

In this paper, 7 portable glucose analysis technologies were evaluated and i-STAT was determined to have the best correlation and best coefficient of determination for high and low values in comparisons to reference methods. A concluding quote from this paper is:

"A consensus statement from the American Diabetes Association and the National Institute of Health suggests that results from devices used to self monitor blood glucose concentrations in people should fall within 15 % of results of an established reference method for the device to be clinically useful. On this basis, the only method tested in the present study that would have been considered acceptable was the i-STAT analyzer."

⁴ Shaffran N: Blood gas analysis. Veterinary Technician, Vol 19, No. 2, February 1998, p95 103.

back to top Core Applications
	E3+ Cartridge Sodium Potassium Chloride Hematocrit
	CG8+ Cartridge Sodium Hematocrit Potassium Hemoglobin Ionized Calcium O2 Saturation pH pO2 pCO2 Base Excess Bicarbonate Total CO2 Glucose
	EC8+ Cartridge Sodium Hematocrit Potassium Hemoglobin Chloride TCO2 pH HCO3 pCO2 Base Excess BUN Anion Gap Glucose
	EG7+ Cartridge Sodium pCO2 Potassium Hematocrit Ionized Calcium pO2 sO2 TCO2 HCO3 Hemoglobin pH Base Excess
	6+ Cartridge Sodium Potassium Chloride BUN Glucose Hematocrit Hemoglobin
	CG4+ Cartridge pH pCO2 pO2 HCO3 TCO2 sO2 Base Excess Lactate
	EG6+ Cartridge Sodium Hematocrit Potassium pCO2 HCO3 TCO2 sO2 pO2 pH Hemoglobin Base Excess
Additional Applications
	Crea Cartridge Creatinine
	ACT Cartridge Celite-Activated Coagulation Time
	EC4+ Cartridge Sodium Potassium Glucose Hematocrit Hemoglobin
	G Cartridge Glucose